Treatment of Post-Ablation Bronchopleural Fistula Using Percutaneous Synthetic Hydrogel Surgical Sealant: Initial Experience of Safety and Efficacy - Peeref (2024)

Article Pediatrics

Selective Bronchial Occlusion for Treatment of a Bronchopleural Fistula in an Extremely Preterm Infant

Giacomo Simeone Amelio, Mariarosa Colnaghi, Silvia Gulden, Genny Raffaeli, Valeria Cortesi, Ilaria Amodeo, Giacomo Cavallaro, Fabio Mosca, Stefano Ghirardello

Summary: Neonatal pulmonary air leak is a common complication of mechanical ventilation in infants with hyaline membrane disease. While conservative management or chest drainage can be effective, severe cases may require alternative therapeutic solutions. Selective bronchial occlusion, as described in the study, is a promising unconventional rescue therapy for bronchopleural fistula resistant to standard treatments, showing significant improvement in clinical condition and radiographic findings.

Article Medicine, General & Internal

Pneumoscrotum Caused by a Bronchopleural Fistula

Jean-Paul Noujeim, Serge Ibrahim, Antoine Noujeim, Youssef Haddad

Summary: Pneumoscrotum, characterized by the presence of air in the scrotum, is a rare medical condition with potentially life-threatening causes. Prompt evaluation and treatment are crucial for managing pneumoscrotum effectively.

Review Critical Care Medicine

Bronchopleural Fistula in the Mechanically Ventilated Patient: A Concise Review

John C. Grotberg, Robert C. Hyzy, Jose De Cardenas, Ivan N. Co

Summary: The key to managing bronchopleural fistula in mechanically ventilated patients is to reduce air leak by strategies such as decreasing peak inspiratory pressure, using lower tidal volumes, lowering positive end-expiratory pressure, decreasing inspiratory time, and reducing respiratory rate. Individualized mechanical ventilation and intrapleural catheter management are important.

Article Medicine, General & Internal

Life-threatening Mycobacterium intracellulare pleuritis in an immunocompetent host Case reports

Bo-Gun Kho, Young-Ok Na, Hwa Kyung Park, Jae-Kyeong Lee, Hyung-Joo Oh, Ha-Young Park, Tae-Ok Kim, Hong-Joon Shin, Yong-Soo Kwon, Yu-Il Kim, Sung-Chul Lim

Summary: NTM-associated pleuritis is a rare disease that requires multiple treatment approaches, including drainage and multidrug therapy. Surgical treatment should be considered promptly for complications.

Article Medicine, General & Internal

Bronchopleural fistula causing persistent pneumothorax in COVID-19 pneumonia patient with no risk factors

Mhd Baraa Habib, Ibrahim Mohammad Obeidat, Khaled Ali, Mohamed Abdelrazek, Mouhand F. H. Mohamed

Summary: This case illustrates the rare occurrence of bronchopleural fistula in COVID-19 pneumonia, even in the absence of risk factors or mechanical ventilation administration.

Article Medicine, General & Internal

Secondary Pneumothorax Induced by a Bronchopleural Fistula in a Patient With COVID-19 Pneumonia

Connor Smith, Olivia Mobarakai, Amber Bux, Ralph Kamel, Neville Mobarakai

Summary: COVID-19, caused by SARS-CoV-2, is a multi-system disease characterized by pneumonia complicated by adult respiratory distress syndrome. While spontaneous pneumothorax has been reported in some COVID-19 patients, bronchopleural fistula has rarely been reported as the primary cause. We describe a rare case of a young patient who developed pneumothorax complicating COVID-19 and was found to have a bronchopleural fistula and empyema secondary to Staphylococcus aureus superinfection.

Article Medicine, General & Internal

Bronchopleural fistula associated persistent pneumothorax in a patient recovering from COVID-19 pneumonia: A case report

Milan Regmi, Anurag Karki, Moon Shrestha, Nibesh Pathak, Sanjeev Bhandari, Niraj Kumar Sharma, Pankaj Pant

Summary: Pneumothorax and bronchopleural fistula (BPF) are potentially fatal complications that can occur in patients with COVID-19 pneumonia. Early detection, appropriate treatment, and consideration of surgical intervention are necessary for optimum outcomes.

Article Medicine, General & Internal

Bronchopleural fistula and bilateral pneumothorax in a patient with COVID-19

Sangam Shah, Prince Mandal, Rajan Chamlagain, Rukesh Yadav, Yubraj Pande, Sanjit Kumar Sah, Basanta Sharma Paudel, Madan Gyawali

Summary: Complications of COVID-19 pneumonia may include pneumothorax, hydropneumothorax, and bronchopleural fistula. In this case, a 24-year-old man developed pneumothorax, hydropneumothorax, and BPF after COVID-19 infection.

Article Emergency Medicine

Young patient with pneumonia complicated by bronchopleural fistula

Maria Mohammed Fariduddin, Kai Wang, Ayesha Birjees, Wajihuddin Syed

Summary: The case involves a 19-year-old female presenting with pneumonia and sepsis, complicated by empyema and bronchopleural fistula. Bronchopleural fistula is a rare complication that requires surgical or bronchoscopic intervention and adjustment of ventilator settings to support respiratory function. Recognizing and managing a BPF promptly in the emergency setting is crucial for ensuring patients receive appropriate treatment for the fistula.

Review Medicine, General & Internal

Bronchopleural Fistula and Endobronchial Valve Placement in a Patient With COVID-19 Pneumonia: A Case Report With Literature Review

Zaryab Umar, Usman Ilyas, Salman Ashfaq, Deesha Shah, Mahmoud Nassar, Theo Trandafirescu

Summary: Bronchopleural fistulas (BPFs) are a serious complication associated with high morbidity and mortality in COVID-19 patients. This case report presents an 86-year-old male with COVID-19 pneumonia and subsequent BPF, who experienced persistent air leak. The use of endobronchial valves resulted in successful cessation of the air leak, providing guidance for managing this condition.

Article Medicine, General & Internal

Bronchopleural fistula associated persistent pneumothorax in a patient recovering from COVID-19 pneumonia: A case report

Milan Regmi, Anurag Karki, Moon Shrestha, Nibesh Pathak, Sanjeev Bhandari, Niraj Kumar Sharma, Pankaj Pant

Summary: This article discusses a case of a 57-year-old male with COVID-19 pneumonia who developed bilateral crepitations and right-sided pneumothorax that persisted despite chest tube insertion.

Article Oncology

Postoperative bronchopleural fistula after induction therapy with bevacizumab

Hironobu Wada, Hidemi Suzuki, Kazuhisa Tanaka, Yuichi Sakairi, Ichiro Yoshino

Summary: Bronchopleural fistulas are rare complications of bevacizumab treatment. This case report describes a patient who developed a bronchopleural fistula after undergoing bevacizumab therapy for lung cancer. Surgical repair of the fistula using muscle flaps resulted in satisfactory healing and the patient remained alive without recurrence for 5 years. Careful postoperative management is necessary when using bevacizumab for induction therapy.

Article Cardiac & Cardiovascular Systems

Prevalence and treatment outcome of bronchopleural fistula: a multi-center study in Ethiopia

Samuel Tesfaye Woldemariam, Israel Bekele Molla, Seyoum Kassa Merine, Dereje Gulilat Yilma

Summary: This study assessed the prevalence, risk factors, and management outcomes of bronchopleural fistula patients in multiple centers in Ethiopia. The study found that having thoracic surgery is a risk factor for the development of bronchopleural fistula, and individualized treatment is necessary.

Editorial Material Cardiac & Cardiovascular Systems

A novel technique for Endobronchial Watanabe Spigot placement for bronchopleural fistula: a traction method

Naoki Date, Teruya Komatsu, Takuji Fujinaga

Summary: Closing bronchopleural fistula with a spigot using the new 'traction method' by tying the spigot to a guidewire as an anchor and pulling it into the target bronchus allows for selective and steady placement, providing an effective solution for patients undergoing open-window thoracostomy.

Article Respiratory System

Therapeutic closure of bronchopleural fistulas using ethanol

Osheen Abramian, Justin Rosenheck, Diana Taddeo-Kolman, Francis Bowen, Ziad Boujaoude, Wissam Abouzgheib

Summary: Bronchopleural fistula (BPF) leading to persistent air leak (PAL) is a serious complication following pulmonary surgery, associated with high morbidity and mortality. Management options include surgical and bronchoscopic techniques, with individualized treatment plans based on patient characteristics.

Article Cardiac & Cardiovascular Systems

Rip2 modifies VEGF-induced signalling and vascular permeability in myocardial ischaemia

Linda Andersson, Margareta Scharin Tang, Annika Lundqvist, Malin Lindbom, Ismena Mardani, Per Fogelstrand, Puja Shahrouki, Bjorn Redfors, Elmir Omerovic, Max Levin, Jan Boren, Malin C. Levin

Review Surgery

Management Options for Gastric Variceal Hemorrhage

Edward Wolfgang Lee, Puja Shahrouki, Lourdes Alanis, Pengxu Ding, Stephen T. Kee

Article Surgery

Intermodality feature fusion combining unenhanced computed tomography and ferumoxytol-enhanced magnetic resonance angiography for patient-specific vascular mapping in renal impairment

Takegawa Yoshida, Kim-Lien Nguyen, Puja Shahrouki, William J. Quinones-Baldrich, Peter F. Lawrence, J. Paul Finn

Article Radiology, Nuclear Medicine & Medical Imaging

Minimizing table time in patients with claustrophobia using focused ferumoxytol-enhanced MR angiography (f-FEMRA): a feasibility study

Puja Shahrouki, Kim-Lien Nguyen, John M. Moriarty, Adam N. Plotnik, Takegawa Yoshida, J. Paul Finn

Summary: In patients with claustrophobia, the rapid, focused ferumoxytol-enhanced MR angiography protocol (f-FEMRA) achieved high acceptance and provided comprehensive vascular imaging of the thorax, abdomen, and pelvis within 5 minutes, with good image quality and diagnostic confidence.

Article Radiology, Nuclear Medicine & Medical Imaging

Polysplenia syndrome and sickle cell trait: extensive deep venous thrombosis from venous stasis and hypercoagulability

Puja Shahrouki, Edward Wolfgang Lee, Stefan Ruehm

Summary: This case report describes a patient with polysplenia syndrome and sickle cell trait, complicated by extensive deep venous thrombosis refractory to medical and interventional radiologic treatment.

Article Gastroenterology & Hepatology

Safety of Irreversible Electroporation Ablation of the Pancreas

Edward Wolfgang Lee, Puja Shahrouki, Stephanie Peterson, Bashir A. Tafti, Peng-Xu Ding, Stephen T. Kee

Summary: IRE ablation of swine pancreatic tissue showed minimal complications and no apparent functional impairment on vital structures. The results suggest IRE as a potential alternative treatment modality for patients with pancreatic cancer.

Letter Gastroenterology & Hepatology

Irreversible Electroporation A Novel Treatment Modality in Locally Advanced and Unresectable Pancreatic Adenocarcinoma

Puja Shahrouki, Edward Wolfgang Lee

Article Pediatrics

High-resolution three-dimensional contrast-enhanced magnetic resonance venography in children: comparison of gadofosveset trisodium with ferumoxytol

Puja Shahrouki, Sarah N. Khan, Takegawa Yoshida, Paul J. Iskander, Shahnaz Ghahremani, J. Paul Finn

Summary: This study compared gadofosveset trisodium and ferumoxytol for high-resolution MR venography in children, finding that ferumoxytol had higher SNR and CNR for the inferior vena cava, better image quality and vessel definition, and more stable venous signal over time compared to gadofosveset trisodium. There were no adverse reactions to either contrast agent. Ferumoxytol was concluded to offer a wider time window for optimal image acquisition and a near-ideal approach to high-resolution venography in children.

Meeting Abstract Clinical Neurology

Defining Ischemic Core In Acute Ischemic Stroke Using CT Perfusion: A Multicenter Validation Study

Puja Shahrouki, Johanna T. Fifi, Adam Bauer, Achala Vagal, Pooja Khatri, Ashok Srinivasan, Margarita Arango-Lievano, Anca Mitulescu, Sophie Campana-Tremblay, Brianna Bucciarelli, James Sayre, Hazem Shoirah, J. D. Mocco, Kambiz Nael

Letter Immunology

Severe COVID-19 Pneumonia of Single Transplant Lung Sparing Native Fibrotic Lung

Puja Shahrouki, Michael C. Fishbein, Arash Bedayat

Article Radiology, Nuclear Medicine & Medical Imaging

Steady-state ferumoxytol-enhanced MRI: early observations in benign abdominal organ masses and clinical implications

Puja Shahrouki, Ely R. Felker, Steven S. Raman, Woo Kyoung Jeong, David S. Lu, J. Paul Finn

Summary: The study on the off-label use of ferumoxytol as a vascular MR imaging agent showed that it plays an important role in the detection and characterization of benign abdominal mass lesions. The enhancement characteristics of ferumoxytol helped increase diagnostic confidence for benign masses and were consistent with other imaging modalities and follow-up results.

Article Chemistry, Multidisciplinary

Single Puncture TIPS-A 3D Fusion Image-Guided Transjugular Intrahepatic Portosystemic Shunt (TIPS): An Experimental Study

Edward Wolfgang Lee, Puja Shahrouki, Sammy Saab, Fady Kaldas, Navid Eghbalieh, Justin McWilliams, Peng-Xu Ding, Stephen T. Kee

Summary: This study demonstrated the safety and effectiveness of real-time 3D fusion image-guided single puncture TIPS, with a high success rate and no peri-procedural complications. The method can significantly reduce complications associated with portal hypertension procedures.

Article Cardiac & Cardiovascular Systems

High resolution, 3-dimensional Ferumoxytol-enhanced cardiovascular magnetic resonance venography in central venous occlusion

Puja Shahrouki, John M. Moriarty, Sarah N. Khan, Biraj Bista, Stephen T. Kee, Brian G. DeRubertis, Takegawa Yoshida, Kim-Lien Nguyen, J. Paul Finn